Measurement of Therapeutic Response
in Chronic Graft-versus-Host Disease

The links below lead to data collection forms and information for measuring disease response in chronic GvHD-related clinical trials.

•   Overview of Chronic GvHD Response Assessment
    View Files Online                                
    Download All Files  (77MB ZIP File)

 •  Response Criteria APPENDIX A:   
    Data Collection Form A – Clinical Assessment

 •  Response Criteria APPENDIX B: 
    Data Collection Form B – Patient Self Report

•   Response Criteria APPENDICES C & D: 
    Proposed Calculations for Partial Response in Chronic GVHD,  
    and Proposed Calculations for Progression in Chronic GVHD

•   Response Criteria Attachment 1: 
    Literature Review of Various Response Criteria Used in Chronic
    Graft-versus-Host Disease Clinical Trails  (By Gorgun Akpek)

•   Response Criteria Attachment 2: 
    Glossary

•   Response Criteria Attachment 3: 
    Skin Body Surface Area Calculation Worksheet

•   Response Criteria Attachment 4: 
    Body Surface Area Assessment in Children Younger Than
    1 Year of Age

•   Response Criteria Attachment 5: 
    Patient Reported Outcome Measure Recommended for
    Chronic GvHD Response

For more information about this GvHD measurement system, see Pavletic SZ, Martin P, Lee SJ et al.  Measuring Therapeutic Response in Chronic Graft-versus-Host Disease:  National Institutes of Health Consensus Development Project for Clinical Trials in Graft-versus-Host Disease:  IV.  Response Criteria Working Group Report, Biol Blood Marrow Transplant. 2006 Mar;12(3):252-66.

Ancillary Care:  Specific Dispensary Guidelines

•   Dispensary Guidelines 
   
For more information about ancillary therapy and supportive care, see Couriel D, Carpenter PA,  Cutler C et al. Ancillary Therapy and Supportive Care of Chronic Graft-versus-Host Disease:  National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease:  V. Ancillary Therapy and Supportive Care Working Group Report, Biol Blood Marrow Transplant. 2006 Apr;12(4)375-396.